Rhodium-Catalyzed C-C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers
2010
Abstract
A rhodium-catalyzed enantioselective insertion into the C-C bond of tert-cyclobutanols and subsequent proto-demetalation provides access to Me substituted quaternary stereogenic centers in excellent yields and enantioselectivities. The reaction was used for a synthesis of (S)-4-ethyl-4-methyl-octane, the simplest satd. hydrocarbon with a quaternary stereogenic center.
Details
Title
Rhodium-Catalyzed C-C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers
Author(s)
Seiser, Tobias ; Cramer, Nicolai
Published in
Journal of the American Chemical Society
Volume
132
Pages
5340-5341
Date
2010
Publisher
American Chemical Society
ISSN
0002-7863
Keywords
Note
CAPLUS AN 2010:396037(Journal)
Laboratories
LCSA
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCSA - Laboratory of Asymmetric Catalysis and Synthesis
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date
2011-08-17