Highly selective rhodium catalyzed domino C-H activation/cyclizations
The direct functionalization of carbon-hydrogen bonds is an emerging tool to establish more sustainable and efficient synthetic methods. We present its implementation in a cascade reaction that provides a rapid assembly of functionalized indanylamines from simple and readily available starting materials. Careful choice of the ancillary ligand - an electron-rich bidentate phosphine ligand - enables highly diastereoselective rhodium(I)-catalyzed intramol. allylations of unsubstituted ketimines induced by a directed C-H bond activation and allene carbo-metalation sequence.
Keywords: Allene ; Allylation ; C-H Activation ; Catalysis ; Rhodium ; Quaternary Stereogenic Centers ; Bond Formation ; Enantioselective Synthesis ; Reverse Prenylation ; Activation ; Cleavage ; Functionalization ; Arylation ; Construction ; Derivatives
CAPLUS AN 2011:677119(Journal)
Record created on 2011-08-17, modified on 2016-08-09