Nutrichip: an integrated microfluidic system for in vitro investigation of the immunemodulatory function of dairy products
Ramadan, Qasem; Jafarpoorchekab, Hamideh; Bolanz, Katrin; Schwander, Flurina; Silacci, Paolo; Carrara, Sandro; Ramsden, Jeremy; Vergeres, Guy; Gijs, Martinus
2011

Abstract

We introduce the concept of the NutriChip, a miniaturized artificial human gastrointestinal tract (GIT) for investigating the potential of immuno-modulatory function of dairy food. More specifically, we are investigating the effect of digested milk on immune cells activation by creating conditions close to those of the human GIT employing an in vitro model of hu-man GIT epithelial cells (Caco-2) in co-culture with human immune cells (differentiated THP-1). The cytokines (IL1/6) and Toll-like receptors (TLR-2/4) expressions by the immune cells will be monitored upon the application of dairy food on the epithelial cell layer.

Details

Title Nutrichip: an integrated microfluidic system for in vitro investigation of the immunemodulatory function of dairy products
Author(s) Ramadan, Qasem ; Jafarpoorchekab, Hamideh ; Bolanz, Katrin ; Schwander, Flurina ; Silacci, Paolo ; Carrara, Sandro ; Ramsden, Jeremy ; Vergeres, Guy ; Gijs, Martinus
Published in Proceedings of the 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS)
Conference 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Seattle, Washington, USA, October 2-6, 2011
Date 2011
Keywords
Laboratories LSI1
LMIS2
Record Appears in Scientific production and competences > I&C - School of Computer and Communication Sciences > IINFCOM > LSI1 - Integrated Systems Laboratory 1 (STI/IC)
Scientific production and competences > STI - School of Engineering > IEM - Institut d'Electricité et de Microtechnique > LMIS2 - Microsystems Laboratory 2
Peer-reviewed publications
Conference Papers
Work produced at EPFL
Published
Record creation date 2011-08-04

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