The goal is to develop a miniaturized system allowing continuous measurement of glucose concentration profiles over 24 hours for several days. The unique feature of the PharmaSens / IMT approach lies in the insertion mechanism and the needle size to assure optimum user-friendliness and patient comfort. The measurement method is based on classical amperometric detection using an enzymatic membrane. The sensor substrate is made on a flexprint substrate and consists of a 3-electrode cell on a needle-shaped tip of ~100 μm width and is covered with polymeric membranes. The sensor is integrated in a device that combines the insertion mechanism and electronics.