Infoscience

Journal article

A whole-genome association study of major determinants for host control of HIV-1

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.

    Keywords: Genome, Human

    Note:

    Comment in: Science. 2007 Oct 19;318(5849):390-1; author reply 390-1

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    Record created on 2011-04-15, modified on 2016-08-09

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