Host determinants of HIV-1 control in African Americans

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.


Published in:
The Journal of infectious diseases, 201, 8, 1141-9
Year:
2010
ISSN:
1537-6613
Keywords:
Note:
Erratum in: J Infect Dis. 2010 Aug 15;202(3):501 Comment in: J Infect Dis. 2010 Apr 15;201(8):1118-20
Laboratories:




 Record created 2011-04-11, last modified 2018-03-17

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