Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
Thompson, Alexander J.; Muir, Andrew J.; Sulkowski, Mark S.; Ge, Dongliang; Fellay, Jacques; Shianna, Kevin V.; Urban, Thomas; Afdhal, Nezam H.; Jacobson, Ira M.; Esteban, Rafael; Poordad, Fred; Lawitz, Eric J.; McCone, Jonathan; Shiffman, Mitchell L.; Galler, Greg W.; Lee, William M.; Reindollar, Robert; King, John W.; Kwo, Paul Y.; Ghalib, Reem H.; Freilich, Bradley; Nyberg, Lisa M.; Zeuzem, Stefan; Poynard, Thierry; Vock, David M.; Pieper, Karen S.; Patel, Keyur; Tillmann, Hans L.; Noviello, Stephanie; Koury, Kenneth; Pedicone, Lisa D.; Brass, Clifford A.; Albrecht, Janice K.; Goldstein, David B.; McHutchison, John G.
2010

Abstract

We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotype 1 (HCV-1) infection. We sought to confirm the polymorphism's clinical relevance by intention-to-treat analysis evaluating on-treatment virologic response and SVR.

Details

Title Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
Author(s) Thompson, Alexander J. ; Muir, Andrew J. ; Sulkowski, Mark S. ; Ge, Dongliang ; Fellay, Jacques ; Shianna, Kevin V. ; Urban, Thomas ; Afdhal, Nezam H. ; Jacobson, Ira M. ; Esteban, Rafael ; Poordad, Fred ; Lawitz, Eric J. ; McCone, Jonathan ; Shiffman, Mitchell L. ; Galler, Greg W. ; Lee, William M. ; Reindollar, Robert ; King, John W. ; Kwo, Paul Y. ; Ghalib, Reem H. ; Freilich, Bradley ; Nyberg, Lisa M. ; Zeuzem, Stefan ; Poynard, Thierry ; Vock, David M. ; Pieper, Karen S. ; Patel, Keyur ; Tillmann, Hans L. ; Noviello, Stephanie ; Koury, Kenneth ; Pedicone, Lisa D. ; Brass, Clifford A. ; Albrecht, Janice K. ; Goldstein, David B. ; McHutchison, John G.
Published in Gastroenterology
Volume 139
Issue 1
Pages 120-9
Date 2010
ISSN 1528-0012
Keywords
DOI https://doi.org/10.1053/j.gastro.2010.04.013
Laboratories GR-FE
Record Appears in Scientific production and competences > SV - School of Life Sciences > GHI - Global Health Institute > GR-FE - Fellay Group
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2011-04-11

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