Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
Thompson, Alexander J.; Fellay, Jacques; Patel, Keyur; Tillmann, Hans L.; Naggie, Susanna; Ge, Dongliang; Urban, Thomas J.; Shianna, Kevin V.; Muir, Andrew J.; Fried, Michael W.; Afdhal, Nezam H.; Goldstein, David B.; McHutchison, John G.
2010

Abstract

In a genome-wide association study of patients being treated for chronic hepatitis C, 2 functional variants in ITPA that cause inosine triphosphatase (ITPase) deficiency were shown to protect against ribavirin (RBV)-induced hemolytic anemia during early stages of treatment. We aimed to replicate this finding in an independent cohort from the Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C and to investigate the effects of these variants beyond week 4.

Details

Title Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
Author(s) Thompson, Alexander J. ; Fellay, Jacques ; Patel, Keyur ; Tillmann, Hans L. ; Naggie, Susanna ; Ge, Dongliang ; Urban, Thomas J. ; Shianna, Kevin V. ; Muir, Andrew J. ; Fried, Michael W. ; Afdhal, Nezam H. ; Goldstein, David B. ; McHutchison, John G.
Published in Gastroenterology
Volume 139
Issue 4
Pages 1181-9
Date 2010
ISSN 1528-0012
Keywords
DOI https://doi.org/10.1053/j.gastro.2010.06.016
Laboratories GR-FE
Record Appears in Scientific production and competences > SV - School of Life Sciences > GHI - Global Health Institute > GR-FE - Fellay Group
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2011-04-11

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