Infoscience

Journal article

Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population

Petrovski, Slavé; Fellay, Jacques; Shianna, Kevin V.; Carpenetti, Nicole; Kumwenda, Johnstone; Kamanga, Gift; Kamwendo, Deborah D.; Letvin, Norman L.; McMichael, Andrew J.; Haynes, Barton F.
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  • Published in: AIDS, vol. 25, num. 4, p. 513-8
  • Publication date: 2011

To date, CCR5 variants remain the only human genetic factors to be confirmed to impact HIV-1 acquisition. However, protective CCR5 variants are largely absent in African populations, in which sporadic resistance to HIV-1 infection is still unexplained. We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans.

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