In this paper, the impact of the wire grid size on the power-delay-area trade off of VLSI digital circuits with differential routing is analyzed. To this aim, the differential MOS current-mode logic (MCML) is adopted as reference logic style, and a complete differential design flow is used. Analysis shows that the choice of the grid size in differential routing has a much stronger impact on the power-delay-area tradeoff, compared to the usual single-ended case. Hence, the grid size is an important knob that must be carefully selected when differential routing is adopted. The dependence of power, delay and area on the grid size is discussed indetail through simple models, and introducing appropriate metrics. To validate the analysis and show basic dependencies impractical circuits, 30 benchmark circuits with an in-house designed MCML cell library were synthesized and routed in 0.18 mm CMOS technology. Results show thatnon-optimal choice of the grid size can determine a dramatic increase in power (1.7x) and area (1.3x). Interestingly, the grid size that optimizes the power-delay-area tradeoff is almost independent of the specific circuit under design; hence a generally optimum grid size exists that optimizes a very wide range of different circuits.