Chiral Phosphoric Acid-Catalyzed Enantioselective Transfer Hydrogenation of ortho-Hydroxyaryl Alkyl N-H Ketimines

The first enantioselective chiral phosphoric acid-catalyzed transfer hydrogenation of unprotected ortho-hydroxyaryl alkyl N-H ketimines using Hantszch di-tert-butyl ester as a reductant is reported. A variety of ortho-hydroxybenzylamines were obtained in good to excellent yields and enantiomeric excesses.


Published in:
Organic Letters, 12, 20, 4705-4707
Year:
2010
Publisher:
American Chemical Society
ISSN:
1523-7060
Laboratories:




 Record created 2011-02-17, last modified 2018-09-13


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