Chiral Calcium Organophosphate-Catalyzed Enantioselective Electrophilic Amination of Enamides
2011
Abstract
Highly enantioselective direct amination of enamides catalyzed by chiral nonracemic calcium bis(phosphate) complex 3g afforded optically active 1,2-hydrazinoimines 4. Following a subsequent in situ hydrolysis or reduction, 2-hydrazinoketones 5 or syn-1,2-disubstituted 1,2- diamines 6 were obtained in high yields and excellent enantiomeric excess.
Details
Title
Chiral Calcium Organophosphate-Catalyzed Enantioselective Electrophilic Amination of Enamides
Author(s)
Drouet, Fleur ; Lalli, Claudia ; Liu, Hua ; Masson, Geraldine ; Zhu, Jieping
Published in
Organic Letters
Volume
13
Issue
1
Pages
94-97
Date
2011
Publisher
American Chemical Society
ISSN
1523-7060
Keywords
Other identifier(s)
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Laboratories
LSPN
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2011-02-17