Chiral Calcium Organophosphate-Catalyzed Enantioselective Electrophilic Amination of Enamides
Highly enantioselective direct amination of enamides catalyzed by chiral nonracemic calcium bis(phosphate) complex 3g afforded optically active 1,2-hydrazinoimines 4. Following a subsequent in situ hydrolysis or reduction, 2-hydrazinoketones 5 or syn-1,2-disubstituted 1,2- diamines 6 were obtained in high yields and excellent enantiomeric excess.
Keywords: Asymmetric Alpha-Amination ; Transition-Metal Catalysis ; Bond-Forming Reactions ; Bronsted Acid Catalysis ; Stereoselective C-C ; Ene-Type Reaction ; Phosphoric-Acid ; Reductive Amination ; Carbonyl-Compounds ; Amino-Acids
Record created on 2011-02-17, modified on 2016-08-09