Chiral Calcium Organophosphate-Catalyzed Enantioselective Electrophilic Amination of Enamides

Highly enantioselective direct amination of enamides catalyzed by chiral nonracemic calcium bis(phosphate) complex 3g afforded optically active 1,2-hydrazinoimines 4. Following a subsequent in situ hydrolysis or reduction, 2-hydrazinoketones 5 or syn-1,2-disubstituted 1,2- diamines 6 were obtained in high yields and excellent enantiomeric excess.


Published in:
Organic Letters, 13, 1, 94-97
Year:
2011
Publisher:
American Chemical Society
ISSN:
1523-7060
Keywords:
Laboratories:




 Record created 2011-02-17, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)