000162208 001__ 162208
000162208 005__ 20190316235018.0
000162208 0247_ $$2doi$$a10.1016/j.ydbio.2010.12.034
000162208 022__ $$a0012-1606
000162208 02470 $$2ISI$$a000288048300006
000162208 037__ $$aARTICLE
000162208 245__ $$aA regulatory ‘landscape effect’ over the Hoxd cluster
000162208 269__ $$a2011
000162208 260__ $$bElsevier$$c2011
000162208 336__ $$aJournal Articles
000162208 500__ $$aJournal article Developmental biology Dev Biol
000162208 520__ $$aFaithful expression of Hox genes in both time and space is essential for proper patterning of the primary body axis. Transgenic approaches in vertebrates have suggested that this collinear activation process is regulated in a largely gene cluster-autonomous manner. In contrast, more recently co-opted expression specificities, required in other embryonic structures, depend upon long-range enhancer sequences acting from outside the gene clusters. This regulatory dichotomy was recently questioned, since gene activation along the trunk seems to be partially regulated by signals located outside of the cluster. We investigated these alternative regulatory strategies by engineering a large inversion that precisely separates the murine HoxD complex from its centromeric neighborhood. Mutant animals displayed posterior transformations along with subtle deregulations of Hoxd genes, indicating an impact of the centromeric landscape on the fine-tuning of Hoxd gene expression. Proximal limbs were also affected, suggesting that this 'landscape effect' is generic and impacts upon regulatory mechanisms of various qualities and evolutionary origins.
000162208 700__ $$aTschopp, Patrick
000162208 700__ $$g141236$$aDuboule, Denis$$0240276
000162208 773__ $$j351$$tDevelopmental Biology$$q288-296
000162208 8564_ $$uhttps://infoscience.epfl.ch/record/162208/files/Tschopp-2010-A%20Regulatory%20%27Landsc.pdf$$zn/a$$s580786$$yn/a
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000162208 917Z8 $$x182482
000162208 917Z8 $$x182482
000162208 917Z8 $$x148230
000162208 937__ $$aEPFL-ARTICLE-162208
000162208 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000162208 980__ $$aARTICLE