000161831 001__ 161831
000161831 005__ 20181203022240.0
000161831 0247_ $$2doi$$a10.1021/ml100081e
000161831 02470 $$2ISI$$a000284203100003
000161831 037__ $$aARTICLE
000161831 245__ $$aCytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodo-platinum(II) complex
000161831 269__ $$a2010
000161831 260__ $$c2010
000161831 336__ $$aJournal Articles
000161831 520__ $$aNovel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
000161831 6531_ $$aIodidoplatinum complex
000161831 6531_ $$acytotoxicity
000161831 6531_ $$aDNA and protein interaction
000161831 6531_ $$aMetallodrug-Protein Interactions
000161831 6531_ $$aPlatinum Antitumor Drugs
000161831 6531_ $$aHeart Cytochrome-C
000161831 6531_ $$aMass-Spectrometry
000161831 6531_ $$aDna
000161831 6531_ $$aEsi
000161831 6531_ $$aPlatination
000161831 6531_ $$aCompound
000161831 6531_ $$aInsights
000161831 6531_ $$aPyridine
000161831 700__ $$aMessori, L.
000161831 700__ $$0242064$$g185115$$aCasini, Angela
000161831 700__ $$aGabbiani, C.
000161831 700__ $$aMichelucci, E.
000161831 700__ $$aCubo, L.
000161831 700__ $$aRíos-Luci, C.
000161831 700__ $$aPadrón, J. M.
000161831 700__ $$aNavarro-Ranninger, C.
000161831 700__ $$aQuiroga, A. G.
000161831 773__ $$j1$$tMedChemLetters $$q381–385
000161831 909C0 $$xU9$$0252010$$pLCOM
000161831 909CO $$pSB$$particle$$ooai:infoscience.tind.io:161831
000161831 917Z8 $$x179141
000161831 937__ $$aEPFL-ARTICLE-161831
000161831 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000161831 980__ $$aARTICLE