Cytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodo-platinum(II) complex
Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
Keywords: Iodidoplatinum complex ; cytotoxicity ; DNA and protein interaction ; Metallodrug-Protein Interactions ; Platinum Antitumor Drugs ; Heart Cytochrome-C ; Mass-Spectrometry ; Dna ; Esi ; Platination ; Compound ; Insights ; Pyridine
Record created on 2010-12-20, modified on 2016-08-09