Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics

Plaque-prone areas are exposed to a particular hemodynamic environment characterized by a low mean shear stress value and a cyclic reversal flow. This mechanical environment, also termed oscillatory shear stress (OSS), induces the expression of several pro-atherogenic genes in the endothelial cells including the preproendothelin-1 (ppET-1) gene. The present paper investigates the molecular mechanisms of this induction.


Published in:
Atherosclerosis, 194, 2, 383-90
Year:
2007
ISSN:
1879-1484
Laboratories:




 Record created 2010-12-16, last modified 2018-01-28


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