Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension.
Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we investigated the potential cardiovascular therapeutic effects of a long-term treatment with an arginase inhibitor in adult spontaneously hypertensive rats (SHR) with fully developed hypertension.
Keywords: Arginase ; Arteries ; Endothelial function ; Remodelling ; Spontaneously hypertensive rat ; Blood-Pressure Reduction ; Nitric-Oxide ; Endothelial Dysfunction ; Smooth-Muscle ; Antihypertensive Treatment ; Resistance Arteries ; Gene Polymorphisms ; Vascular Function ; Stiffness ; Hypertrophy
Record created on 2010-12-16, modified on 2016-08-09