000161668 001__ 161668
000161668 005__ 20190113085821.0
000161668 0247_ $$2doi$$a10.1016/j.jorganchem.2010.01.007
000161668 022__ $$a0022-328X
000161668 02470 $$2ISI$$a000274733800015
000161668 037__ $$aARTICLE
000161668 245__ $$aMannich products of kojic acid and N-heterocycles and their Ru(II)-arene complexes: Synthesis, characterization and stability
000161668 260__ $$bElsevier$$c2010
000161668 269__ $$a2010
000161668 336__ $$aJournal Articles
000161668 520__ $$aRu(II)-η6-p-cymene compds. bearing pyrone-derived ligands, which were obtained by Mannich reactions between kojic acid and piperidine or morpholine analogs, have been synthesized. The compds. were characterized by NMR spectroscopy, mass spectrometry, thermogravimetric anal. and, in the case of 2,6-dimethylmorpholine-derived ligand I, by x-ray diffraction anal. The chlorido complexes are prone to aquation in aq. soln. which results in the formation of dimers. Dimer formation can be inhibited by in situ replacement of the chlorido ligand by imidazole yielding compds. which are significantly more stable in water, as demonstrated by 1H NMR spectroscopy.
000161668 6531_ $$aKojic acid
000161668 6531_ $$aMannich reaction
000161668 6531_ $$aRuthenium(II)-arene complexes
000161668 6531_ $$aStability studies
000161668 6531_ $$aSynthesis
000161668 6531_ $$aVitro Anticancer Activity
000161668 6531_ $$aIn-Vitro
000161668 6531_ $$aRuthenium Complexes
000161668 6531_ $$aPreclinical Development
000161668 6531_ $$aMetal-Complexes
000161668 6531_ $$aPhase-I
000161668 6531_ $$aLigands
000161668 6531_ $$aMaltol
000161668 6531_ $$aAgent
000161668 6531_ $$aTyrosinase
000161668 700__ $$aKasser, Johanna H.
000161668 700__ $$aKandioller, Wolfgang
000161668 700__ $$aHartinger, Christian G.
000161668 700__ $$0242063$$g182952$$aNazarov, Alexey A.
000161668 700__ $$aArion, Vladimir B.
000161668 700__ $$g149418$$aDyson, Paul J.$$0240015
000161668 700__ $$aKeppler, Bernhard K.
000161668 773__ $$j695$$tJournal of Organometallic Chemistry$$k6$$q875-881
000161668 909C0 $$xU9$$0252010$$pLCOM
000161668 909CO $$pSB$$particle$$ooai:infoscience.tind.io:161668
000161668 917Z8 $$x179141
000161668 937__ $$aEPFL-ARTICLE-161668
000161668 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000161668 980__ $$aARTICLE