Osmium(II)-versus ruthenium(II)-arene carbohydrate-based anticancer compounds: similarities and differences

The synthesis and in vitro anticancer activity of OsII-arene complexes with carbohydrate-derived phosphite co-ligands are reported. The compds. were characterized by std. methods and the mol. structure of dichlorido(η6-p-cymene)(3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-d-glucofuranoside)osmium(ii) was detd. by x-ray diffraction anal. Complexes with chlorido leaving groups undergo hydrolysis by consecutive formation of aqua compds., followed by cleavage of a P-O bond of sugar phosphite ligands, as demonstrated by NMR studies. These observations are similar to those of analogous RuII-arene complexes; however the rate of hydrolysis is very slow for Os compds. The complexes with oxalato leaving groups resist hydrolysis; no hydrolytic species were detected by 31P{1H} NMR spectroscopy over several days. Within this series of Os compds., in vitro anticancer activity is highest for the most lipophilic chlorido complex dichlorido(η6-p-cymene)(3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-α-d-glucofuranoside)osmium(II).


Published in:
Dalton Transactions , 39, 31, 7345-7352
Year:
2010
Publisher:
Royal Society of Chemistry
ISSN:
1477-9226
Keywords:
Laboratories:




 Record created 2010-12-15, last modified 2018-03-17


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