Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(η6-cymene)(PPh2(o-C6H4O)-κ2-P,O)(pta)]+ and an investigation of its cytotoxic effects

Metal complexes bearing phosphine ligands are attracting increasing attention for their applications in medicinal chem. In particular, organometallic ruthenium-phosphine complexes have been found to exhibit promising antitumor activity. The synthesis, anticancer activity and reactivity of a novel bis-phosphine complex, [Ru(η6-cymene)(PPh2(o-C6H4O)-κ2-P,O)(pta)]Cl (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1.]decane), is presented. The complex appears to exhibit its anticancer effect via a different mechanism to other ruthenium-arene pta complexes with labile co-ligands.


Published in:
Comptes Rendus Chimie , 13, 8-9, 1144-1150
Year:
2010
Publisher:
Elsevier
ISSN:
1631-0748
Keywords:
Laboratories:




 Record created 2010-12-14, last modified 2018-09-25


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