Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(η6-cymene)(PPh2(o-C6H4O)-κ2-P,O)(pta)]+ and an investigation of its cytotoxic effects
Metal complexes bearing phosphine ligands are attracting increasing attention for their applications in medicinal chem. In particular, organometallic ruthenium-phosphine complexes have been found to exhibit promising antitumor activity. The synthesis, anticancer activity and reactivity of a novel bis-phosphine complex, [Ru(η6-cymene)(PPh2(o-C6H4O)-κ2-P,O)(pta)]Cl (pta = 1,3,5-triaza-7-phosphatricyclo[188.8.131.52.]decane), is presented. The complex appears to exhibit its anticancer effect via a different mechanism to other ruthenium-arene pta complexes with labile co-ligands.
Keywords: Cancer chemotherapy ; Ru-arene complexes ; Bis-phosphine ; DNA binding ; Protein binding ; Mass spectrometry ; Synthesis ; Transition-Metal-Complexes ; Coordinated Gold Compound ; Flash-Quench Technique ; In-Vitro ; Anticancer Activity ; Ruthenium Complexes ; Antitumor-Activity ; Dna-Binding ; Pta Complexes ; Drugs
Record created on 2010-12-14, modified on 2016-08-09