The katG mRNA of Mycobacterium tuberculosis and Mycobacterium smegmatis is processed at its 5 ' end and is stabilized by both a polypurine sequence and translation initiation

Background: In Mycobacterium tuberculosis and in Mycobacterium smegmatis the furA-katG loci, encoding the FurA regulatory protein and the KatG catalase-peroxidase, are highly conserved. In M. tuberculosis furA-katG constitute a single operon, whereas in M. smegmatis a single mRNA covering both genes could not be found. In both species, specific 5' ends have been identified: the first one, located upstream of the furA gene, corresponds to transcription initiation from the furA promoter; the second one is the katG mRNA 5' end, located in the terminal part of furA.


Published in:
Bmc Molecular Biology, 9, -
Year:
2008
Publisher:
BioMed Central
ISSN:
1471-2199
Keywords:
Laboratories:




 Record created 2010-11-30, last modified 2018-12-03


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