Overexpression of a mutant form of TGFBI/BIGH3 induces retinal degeneration in transgenic mice
2008
Abstract
Purpose: Despite ubiquitous expression of the keratoepithelin (KE) protein encoded by the transforming growth factor beta induced/beta induced gene human clone 3 (TGFBI/BIGH3) gene, corneal dystrophies are restricted to the cornea, and no other tissues are affected. We investigated the role of TGFBI/BIGH3 in Groenouw corneal dystrophies by generating transgenic mice overexpressing TGFBI/BIGH3 containing the R555W mutation.
Details
Title
Overexpression of a mutant form of TGFBI/BIGH3 induces retinal degeneration in transgenic mice
Author(s)
Bustamante, Mauro ; Tasinato, Andrea ; Maurer, Fabienne ; Elkochairi, Ilhem ; Lepore, Mario G. ; Arsenijevic, Yvan ; Pedrazzini, Thierry ; Munier, Francis L. ; Schorderet, Daniel F.
Published in
Molecular Vision
Volume
14
Pages
1129-1137
Date
2008
Keywords
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Laboratories
SV
Record Appears in
Scientific production and competences > Unattributed publications > SV - SV - Unattributed publications
Scientific production and competences > SV - School of Life Sciences > SV - Unattributed publications
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Scientific production and competences > SV - School of Life Sciences > SV - Unattributed publications
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2010-11-30