Multiframe SURE-LET denoising of timelapse fluorescence microscopy images

Due to the random nature of photon emission and the various internal noise sources of the detectors, real timelapse fluorescence microscopy images are usually modeled as the sum of a Poisson process plus some Gaussian white noise. In this paper, we propose an adaptation of our SURE-LET denoising strategy to take advantage of the potentially strong similarities between adjacent frames of the observed image sequence. To stabilize the noise variance, we first apply the generalized Anscombe transform using suitable parameters automatically estimated from the observed data. With the proposed algorithm, we show that, in a reasonable computation time, real fluorescence timelapse microscopy images can be denoised with higher quality than conventional algorithms.

Published in:
2008 Ieee International Symposium On Biomedical Imaging: From Nano To Macro, Vols 1-4, 149-152
Presented at:
5th IEEE International Symposium on Biomedical Imaging - From Nano to Macro, Paris, FRANCE, May 14-17, 2008
Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa

 Record created 2010-11-30, last modified 2018-11-14

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