Differential neuroglycan C expression during retinal degeneration in Rpe65(-/-) mice
Purpose: An increased mRNA expression of the genes coding for the extracellular matrix proteins neuroglycan C (NGC), interphotoreceptor matrix proteoglycan 2 (IMPG2), and CD44 antigen (CD44) has been observed during retinal degeneration in mice with a targeted disruption of the Rpe65 gene (Rpe65(-/-) mouse). To validate these data, we analyzed this differential expression in more detail by characterizing retinal NGC mRNA isoform and protein expression during disease progression.
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Keywords: Chondroitin Sulfate Proteoglycan ; Interphotoreceptor Matrix Proteoglycans ; Lebers Congenital Amaurosis ; Visual Cycle ; Pigment-Epithelium ; Gene-Expression ; Mouse Model ; Egf Family ; Brain ; Identification
Record created on 2010-11-30, modified on 2016-08-09