Differential neuroglycan C expression during retinal degeneration in Rpe65(-/-) mice

Purpose: An increased mRNA expression of the genes coding for the extracellular matrix proteins neuroglycan C (NGC), interphotoreceptor matrix proteoglycan 2 (IMPG2), and CD44 antigen (CD44) has been observed during retinal degeneration in mice with a targeted disruption of the Rpe65 gene (Rpe65(-/-) mouse). To validate these data, we analyzed this differential expression in more detail by characterizing retinal NGC mRNA isoform and protein expression during disease progression.


Published in:
Molecular Vision, 14, 2126-2135
Year:
2008
Keywords:
Laboratories:




 Record created 2010-11-30, last modified 2018-03-17


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