000159786 001__ 159786
000159786 005__ 20181203022202.0
000159786 0247_ $$2doi$$a10.1002/mrm.21961
000159786 022__ $$a0740-3194
000159786 02470 $$2ISI$$a000266429900002
000159786 037__ $$aARTICLE
000159786 245__ $$aMR Spectroscopy of the Human Brain With Enhanced Signal Intensity at Ultrashort Echo Times on a Clinical Platform at 3T and 7T
000159786 260__ $$bWiley-Blackwell$$c2009
000159786 269__ $$a2009
000159786 336__ $$aJournal Articles
000159786 520__ $$aRecently, the spin-echo full-intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full sensitivity and applied to in vivo rat brain. In the present study, SPECIAL was adapted and optimized for use on a clinical platform at 3T and 7T by combining interleaved water suppression (WS) and outer volume saturation (OVS), optimized sequence timing, and improved shimming using FASTMAP. High-quality single voxel spectra of human brain were acquired at TEs below or equal to 6 ms on a clinical 3T and 7T system for six volunteers. Narrow linewidths (6.6 +/- 0.6 Hz at 3T and 12.1 +/- 1.0 Hz at 7T for water) and the high signal-to-noise ratio (SNR) of the artifact-free spectra enabled the quantification of a neurochemical profile consisting of 18 metabolites with Cramer-Rao lower bounds (CRLBs) below 20% at both field strengths. The enhanced sensitivity and increased spectral resolution at 7T compared to 3T allowed a two-fold reduction in scan time, an increased precision of quantification for 12 metabolites, and the additional quantification of lactate with CRLB below 20%. Improved sensitivity at 7T was also demonstrated by a 1.7-fold increase in average SNR (= peak height/root mean square [RMS]-of-noise) per unit-time. Magn Reson Med 61:1279-1285, 2009. (C) 2009 Wiley-Liss, Inc.
000159786 6531_ $$ahuman brain
000159786 6531_ $$aproton magnetic resonance spectroscopy
000159786 6531_ $$ahigh magnetic field
000159786 6531_ $$ashort echo time
000159786 6531_ $$a3T
000159786 6531_ $$a7T
000159786 6531_ $$aVivo H-1-Nmr Spectroscopy
000159786 6531_ $$aIn-Vivo
000159786 6531_ $$aProton Spectroscopy
000159786 6531_ $$aSpectra
000159786 6531_ $$aSensitivity
000159786 6531_ $$aResonances
000159786 6531_ $$aCortex
000159786 6531_ $$aCoils
000159786 6531_ $$aCIBM-AIT
000159786 700__ $$0243740$$aMekle, Ralf$$g169551
000159786 700__ $$0243713$$aMlynarik, Vladimir$$g168843
000159786 700__ $$aGambarota, Giulio
000159786 700__ $$aHergt, Martin
000159786 700__ $$0243728$$aKrueger, Gunnar$$g176711
000159786 700__ $$0243712$$aGruetter, Rolf$$g161735
000159786 773__ $$j61$$q1279-1285$$tMagnetic Resonance In Medicine
000159786 8564_ $$s419733$$uhttps://infoscience.epfl.ch/record/159786/files/Mekle_3T_7T.pdf$$yPublisher's version$$zPublisher's version
000159786 909C0 $$0252477$$pCIBM$$xU12623
000159786 909C0 $$0252276$$pLIFMET$$xU10984
000159786 909CO $$ooai:infoscience.tind.io:159786$$pSB$$particle
000159786 917Z8 $$xWOS-2010-11-30
000159786 917Z8 $$x173008
000159786 917Z8 $$x161735
000159786 917Z8 $$x161735
000159786 917Z8 $$x161735
000159786 937__ $$aEPFL-ARTICLE-159786
000159786 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000159786 980__ $$aARTICLE