Bacteria inactivation and natural organic matter oxidation in river water was simultaneously conducted via photo-Fenton reaction at "natural" pH (similar to 6.5) containing 0.6 mg L-1 of Fe3+ and 10 mg L-1 of H2O2. The experiments were carried out by using a solar compound parabolic collector on river water previously filtered by a slow sand filtration system and voluntarily spiked with Escherichia coli. Fifty five percent of 5.3 mg L-1 of dissolved organic carbon was mineralized whereas total disinfection was observed without re-growth after 24 h in the dark. (C) 2009 Elsevier Ltd. All rights reserved.