An efficient stereoselective and stereodivergent synthesis of (2R,3R)- and (2R,3S)-3-hydroxypipecolic acids

Asymmetric syntheses of (2R,3R) and (2R,3S)-3-hydroxypipecolic acids are reported featuring a key diastereoselective addition of Büchi's Grignard reagent to the chiral serinal Image -5. Based on conformational analysis, a stereocontrolled reduction of piperidin-3-one (15) to cis 2,3-disubstituted piperidine (16) is also described.


Published in:
Tetrahedron Letters, 41, 36, 7033-7036
Year:
2000
Publisher:
Elsevier
ISSN:
0040-4039
Laboratories:




 Record created 2010-11-25, last modified 2018-03-17


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