TubercuList - 10 years after.
TubercuList (http://tuberculist.epfl.ch/), the relational database that presents genome-derived information about H37Rv, the paradigm strain of Mycobacterium tuberculosis, has been active for ten years and now presents its twentieth release. Here, we describe some of the recent changes that have resulted from manual annotation with information from the scientific literature. Through manual curation, TubercuList strives to provide current gene-based information and is thus distinguished from other online sources of genome sequence data for M. tuberculosis. New, mostly small, genes have been discovered and the coordinates of some existing coding sequences have been changed when bioinformatics or experimental data suggest that this is required. Nucleotides that are polymorphic between different sources of H37Rv are annotated and gene essentiality data have been updated. A host of functional information has been gleaned from the literature and many new activities of proteins and RNAs have been included. To facilitate basic and translational research, TubercuList also provides links to other specialized databases that present diverse datasets such as 3D-structures, expression profiles, drug development criteria and drug resistance information, in addition to direct access to PubMed articles pertinent to particular genes. TubercuList has been and remains a highly valuable tool for the tuberculosis research community with >75,000 visitors per month.
Keywords: Tuberculosis ; TubercuList ; H37Rv ; Genome sequence ; Genome annotation ; Database ; Mycobacterium-Tuberculosis H37Rv ; Open Reading Frames ; Messenger-Rna Interferases ; Tandem Mass-Spectrometry ; Complete Genome Sequence ; Toxin-Antitoxin Loci ; Biochemical-Characterization ; Gel-Electrophoresis ; Structural Genomics ; Escherichia-Coli
Record created on 2010-11-25, modified on 2016-08-08