Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline
Bois-Choussy, M.; Cadet, S.; De Paolis, M.; Zhu, J.
2001

Abstract

Pictet–Spengler condensation of β-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1′-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated. Syntheses and functional group transformations of 1,1-disubstituted tetrahydroisoquinoline are reported.

Details

Title Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline
Author(s) Bois-Choussy, M. ; Cadet, S. ; De Paolis, M. ; Zhu, J.
Published in Tetrahedron Letters
Volume 42
Issue 27
Pages 4503-4506
Date 2001
Publisher Elsevier
ISSN 00404039
Keywords
DOI https://doi.org/10.1016/S0040-4039(01)00776-6
Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Work outside EPFL
Journal Articles
Published
Record creation date 2010-11-25

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