Synthesis of hapalosin and 8-deoxy-hapalosin
Wagner, Bjorn; Beugelmans, Rene; Zhu, Jieping
1996

Abstract

Hapalosin, a new MDR reversing agent, and its congener 8-deoxyhapalosin have been synthesized via macrolactamization. A new procedure for selective N-methylation of a vicinal amino alc. is uncovered in the course of this study. [on SciFinder (R)]

Details

Title Synthesis of hapalosin and 8-deoxy-hapalosin
Author(s) Wagner, Bjorn ; Beugelmans, Rene ; Zhu, Jieping
Published in Tetrahedron Letters
Volume 37
Issue 36
Pages 6557-6560
Date 1996
ISSN 0040-4039
Keywords
Note CAN 125:301546
34-3
Amino Acids, Peptides, and Proteins
Inst. Chim. Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
50-00-0 (Formaldehyde); 124-13-0 (Octanal); 13734-34-4; 56267-15-3; 65138-05-8; 101711-78-8 Role: RCT (Reactant), RACT (Reactant or reagent) (synthesis of hapalosin and deoxyhapalosin); 72155-47-6P; 112271-08-6P; 174623-90-6P; 182621-36-9P; 182621-37-0P; 182621-38-1P; 182621-40-5P; 182621-41-6P; 182621-43-8P; 182621-44-9P; 182621-45-0P; 182621-46-1P; 182822-93-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (synthesis of hapalosin and deoxyhapalosin); 159542-04-8P (Hapalosin); 182621-42-7P; 182621-47-2P Role: SPN (Synthetic preparation), PREP (Preparation) (synthesis of hapalosin and deoxyhapalosin)
DOI https://doi.org/10.1016/0040-4039(96)01415-3
Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2010-11-25