Infoscience

Journal article

Synthesis of hapalosin and 8-deoxy-hapalosin

Hapalosin, a new MDR reversing agent, and its congener 8-deoxyhapalosin have been synthesized via macrolactamization. A new procedure for selective N-methylation of a vicinal amino alc. is uncovered in the course of this study. [on SciFinder (R)]

    Keywords: Conformation and Conformers (synthesis of hapalosin and deoxyhapalosin) ; hapalosin prepn; methylation vicinal amino alc

    Note:

    CAN 125:301546

    34-3

    Amino Acids, Peptides, and Proteins

    Inst. Chim. Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.

    Journal

    0040-4039

    written in English.

    50-00-0 (Formaldehyde); 124-13-0 (Octanal); 13734-34-4; 56267-15-3; 65138-05-8; 101711-78-8 Role: RCT (Reactant), RACT (Reactant or reagent) (synthesis of hapalosin and deoxyhapalosin); 72155-47-6P; 112271-08-6P; 174623-90-6P; 182621-36-9P; 182621-37-0P; 182621-38-1P; 182621-40-5P; 182621-41-6P; 182621-43-8P; 182621-44-9P; 182621-45-0P; 182621-46-1P; 182822-93-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (synthesis of hapalosin and deoxyhapalosin); 159542-04-8P (Hapalosin); 182621-42-7P; 182621-47-2P Role: SPN (Synthetic preparation), PREP (Preparation) (synthesis of hapalosin and deoxyhapalosin)

    Reference

    Record created on 2010-11-25, modified on 2016-08-08

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