A method for removal of N-Boc protecting groups from substrates on TFA-sensitive resins

N-tert-butyloxycarbonyl (Boc) groups can be removed from peptides supported on Rink's amide resin by treatment with trimethylsilyl triflate/2,6-lutidine. This methodol. was illustrated here with syntheses of several peptides, but it is likely to be used more extensively in solid phase syntheses of small mol. libraries. [on SciFinder (R)]


Published in:
Tetrahedron Letters, 39, 41, 7439-7442
Year:
1998
Keywords:
Note:
CAN 129:331039
34-3
Amino Acids, Peptides, and Proteins
Department Chemistry,Texas A&M University,College Station,TX,USA.
Journal
0040-4039
written in English.
108-48-5 (2,6-Lutidine); 27607-77-8 (Trimethylsilyl triflate) Role: RCT (Reactant), RACT (Reactant or reagent) (using trimethylsilyl triflate/lutidine for Boc deprotection of peptides bound to TFA-sensitive resins); 60117-24-0P; 64190-70-1P; 215094-76-1P; 215094-77-2P; 215094-78-3P; 215094-79-4P; 215094-80-7P; 215094-81-8P; 215094-82-9P; 215094-83-0P Role: SPN (Synthetic preparation), PREP (Preparation) (using trimethylsilyl triflate/lutidine for Boc deprotection of peptides bound to TFA-sensitive resins)
Laboratories:




 Record created 2010-11-25, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)