An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I
2000
Résumé
An efficient synthesis of K-13 (I), a non-competitive inhibitor of ACE I with an endo biaryl ether bond, is described. The key cycloetherification reaction of linear tripeptide II gave a 17-membered macrocycle in quant. yield. [on SciFinder (R)]
Détails
Titre
An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I
Auteur(s)
Bigot, Antony ; Bois-Choussy, Michele ; Zhu, Jieping
Publié dans
Tetrahedron Letters
Volume
41
Numéro
23
Pages
4573-4577
Date
2000
ISSN
0040-4039
Mots-clés (libres)
Note
CAN 133:223013
34-3
Amino Acids, Peptides, and Proteins
Institut de Chimie des Substances Naturelles, CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
17355-19-0; 188624-33-1; 244769-35-5; 291781-71-0 Role: RCT (Reactant), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 118493-33-7P; 291781-64-1P; 291781-65-2P; 291781-66-3P; 291781-67-4P; 291781-68-5P; 291781-69-6P; 291781-70-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 108890-90-0P; 291781-72-1P Role: SPN (Synthetic preparation), PREP (Preparation) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I)
34-3
Amino Acids, Peptides, and Proteins
Institut de Chimie des Substances Naturelles, CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
17355-19-0; 188624-33-1; 244769-35-5; 291781-71-0 Role: RCT (Reactant), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 118493-33-7P; 291781-64-1P; 291781-65-2P; 291781-66-3P; 291781-67-4P; 291781-68-5P; 291781-69-6P; 291781-70-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 108890-90-0P; 291781-72-1P Role: SPN (Synthetic preparation), PREP (Preparation) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I)
Laboratoires
LSPN
Le document apparaît dans
Production scientifique et compétences > SB - Faculté des sciences de base > ISIC - Institut des sciences et ingénierie chimiques > LSPN - Laboratoire de synthèse et produits naturels
Publications validées par des pairs
Travail hors EPFL
Articles de journaux
Publié
Publications validées par des pairs
Travail hors EPFL
Articles de journaux
Publié
Date de création de la notice
2010-11-25