An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I
2000
Abstract
An efficient synthesis of K-13 (I), a non-competitive inhibitor of ACE I with an endo biaryl ether bond, is described. The key cycloetherification reaction of linear tripeptide II gave a 17-membered macrocycle in quant. yield. [on SciFinder (R)]
Details
Title
An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I
Author(s)
Bigot, Antony ; Bois-Choussy, Michele ; Zhu, Jieping
Published in
Tetrahedron Letters
Volume
41
Issue
23
Pages
4573-4577
Date
2000
ISSN
0040-4039
Keywords
Note
CAN 133:223013
34-3
Amino Acids, Peptides, and Proteins
Institut de Chimie des Substances Naturelles, CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
17355-19-0; 188624-33-1; 244769-35-5; 291781-71-0 Role: RCT (Reactant), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 118493-33-7P; 291781-64-1P; 291781-65-2P; 291781-66-3P; 291781-67-4P; 291781-68-5P; 291781-69-6P; 291781-70-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 108890-90-0P; 291781-72-1P Role: SPN (Synthetic preparation), PREP (Preparation) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I)
34-3
Amino Acids, Peptides, and Proteins
Institut de Chimie des Substances Naturelles, CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
17355-19-0; 188624-33-1; 244769-35-5; 291781-71-0 Role: RCT (Reactant), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 118493-33-7P; 291781-64-1P; 291781-65-2P; 291781-66-3P; 291781-67-4P; 291781-68-5P; 291781-69-6P; 291781-70-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 108890-90-0P; 291781-72-1P Role: SPN (Synthetic preparation), PREP (Preparation) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I)
Laboratories
LSPN
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date
2010-11-25