Infoscience

Journal article

An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I

An efficient synthesis of K-13 (I), a non-competitive inhibitor of ACE I with an endo biaryl ether bond, is described. The key cycloetherification reaction of linear tripeptide II gave a 17-membered macrocycle in quant. yield. [on SciFinder (R)]

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