Studies toward the total synthesis of RP-66453

Synthesis of a bicyclic A-B-O-C ring system of RP-66453 (I), a neurotensine receptor antagonist, with an endo aryl-aryl and an endo aryl-aryl ether bond is described. An alternative synthetic strategy starting from the construction of functionalized B-O-C cycloisodityrosine unit is also detailed. [on SciFinder (R)]


Published in:
Tetrahedron Letters, 43, 14, 2577-2580
Year:
2002
Keywords:
Note:
CAN 137:93981
34-3
Amino Acids, Peptides, and Proteins
CNRS, Institut de Chimie des Substances Naturelles,Gif-sur-Yvette,Fr.
Journal
0040-4039
written in English.
442528-03-2P; 442528-04-3P; 442528-05-4P; 442528-06-5P; 442648-41-1P; 442648-44-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of in the prepn. of bicyclic A-B-O-C ring system of RP-66453); 174698-43-2 Role: MSC (Miscellaneous) (prepn. of bicyclic A-B-O-C ring system of); 442528-07-6P; 442648-47-7P; 442648-50-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of bicyclic A-B-O-C ring system of RP-66453); 44605-74-5; 351442-21-2; 351442-24-5; 442528-02-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of in the prepn. of bicyclic A-B-O-C ring system of RP-66453)
Laboratories:




 Record created 2010-11-25, last modified 2018-03-17


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