Journal article

Reeve's synthesis of 2-imino-4-thiazolidinone from alkyl (aryl) trichloromethylcarbinol revisited, a three-component process from aldehyde, chloroform, and thiourea

An efficient synthesis of 2-imino-4-thiazolidinones from readily accessible alkyl or aryl trichloromethylcarbinols with thioureas, under mild conditions, is reported. A one-pot three-component synthesis of the title compds. from aldehyde, chloroform and thiourea was also developed. [on SciFinder (R)]


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