Asymmetric synthesis of protected γ-carboxy-L-glutamic acid
Couturier, Cedric; Liron, Melanie; Schlama, Thierry; Zhu, Jieping
2005

Abstract

An asym. synthesis of an orthogonally protected gamma -carboxy-L-glutamic acid (L-Gla) is developed featuring a key proline-catalyzed Knoevenagel condensation between Garner's aldehyde and Meldrum's acid. [on SciFinder (R)]

Details

Title Asymmetric synthesis of protected γ-carboxy-L-glutamic acid
Author(s) Couturier, Cedric ; Liron, Melanie ; Schlama, Thierry ; Zhu, Jieping
Published in Synlett
Issue 5
Pages 851-853
Date 2005
ISSN 0936-5214
Keywords
Note CAN 143:26833
34-2
Amino Acids, Peptides, and Proteins
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
609-36-9 (Proline); 13139-17-8 (N-Benzyloxycarbonyloxysuccinamide) Role: CAT (Catalyst use), USES (Uses) (asym. synthesis of protected gamma -carboxy-L-glutamic acid); 2033-24-1 (Meldrum's acid); 10065-72-2; 102308-32-7 (Garner's aldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (asym. synthesis of protected gamma -carboxy-L-glutamic acid); 852536-16-4P; 852536-19-7P; 852536-21-1P; 852536-25-5P; 852536-26-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (asym. synthesis of protected gamma -carboxy-L-glutamic acid); 181637-48-9P; 852536-27-7P; 852536-29-9P Role: SPN (Synthetic preparation), PREP (Preparation) (asym. synthesis of protected gamma -carboxy-L-glutamic acid)
DOI https://doi.org/10.1055/s-2005-863734
Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2010-11-25

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