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Journal article

Asymmetric synthesis of protected gamma -carboxy-L-glutamic acid

An asym. synthesis of an orthogonally protected gamma -carboxy-L-glutamic acid (L-Gla) is developed featuring a key proline-catalyzed Knoevenagel condensation between Garner's aldehyde and Meldrum's acid. [on SciFinder (R)]

    Keywords: Asymmetric synthesis and induction; Knoevenagel reaction (asym. synthesis of protected gamma -carboxy-L-glutamic acid) ; asym synthesis protected gamma carboxyglutamic acid; glutamic acid protected gamma carboxy asym synthesis

    Note:

    CAN 143:26833

    34-2

    Amino Acids, Peptides, and Proteins

    Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.

    Journal

    0936-5214

    written in English.

    609-36-9 (Proline); 13139-17-8 (N-Benzyloxycarbonyloxysuccinamide) Role: CAT (Catalyst use), USES (Uses) (asym. synthesis of protected gamma -carboxy-L-glutamic acid); 2033-24-1 (Meldrum's acid); 10065-72-2; 102308-32-7 (Garner's aldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (asym. synthesis of protected gamma -carboxy-L-glutamic acid); 852536-16-4P; 852536-19-7P; 852536-21-1P; 852536-25-5P; 852536-26-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (asym. synthesis of protected gamma -carboxy-L-glutamic acid); 181637-48-9P; 852536-27-7P; 852536-29-9P Role: SPN (Synthetic preparation), PREP (Preparation) (asym. synthesis of protected gamma -carboxy-L-glutamic acid)

    Reference

    • EPFL-ARTICLE-158115

    Record created on 2010-11-25, modified on 2016-08-08

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