Synthetic studies towards (-)-lemonomycin, synthesis of fused tetracycles
2006
Résumé
The asym. synthesis of 1,3-lactol-bridged tetrahydroisoquinolines I [R = SiMe2CMe3, CH2Ph; R1 = CH2CH(CO2Me)2; R2 = CO2CH2Ph] was developed. Subsequent cyclizations of I (R = SiMe2CMe3, CH2Ph) under acidic conditions lead to the formation of a tricyclic enamides II [R = SiMe2CMe3, CH2Ph; R1 = CH2CH(CO2Me)2; R2 = CO2CH2Ph]. II [R = CH2Ph, R1 = CH2CH(CO2Me)2, R2 = CO2CH2Ph] was in turn converted to a tetracyclic compd. III. [on SciFinder (R)]
Détails
Titre
Synthetic studies towards (-)-lemonomycin, synthesis of fused tetracycles
Auteur(s)
Couturier, Cedric ; Schlama, Thierry ; Zhu, Jieping
Publié dans
Synlett
Numéro
11
Pages
1691-1694
Date
2006
ISSN
0936-5214
Mots-clés (libres)
Note
CAN 145:438438
26-6
Biomolecules and Their Synthetic Analogs
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
200132-54-3 Role: CAT (Catalyst use), USES (Uses) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 276248-62-5P ((-)-Lemonomycin) Role: PNU (Preparation, unclassified), PREP (Preparation) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 100-39-0 (Benzyl bromide); 30934-97-5; 81477-94-3; 225938-52-3; 852536-16-4 Role: RCT (Reactant), RACT (Reactant or reagent) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 912654-98-9P; 912654-99-0P; 912655-00-6P; 912655-01-7P; 912655-02-8P; 912655-03-9P; 912655-04-0P; 912655-05-1P; 912655-11-9P; 912655-12-0P; 912655-13-1P; 912655-14-2P; 912655-15-3P; 912655-16-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 912655-06-2P; 912655-07-3P; 912655-08-4P; 912655-09-5P; 912655-10-8P Role: SPN (Synthetic preparation), PREP (Preparation) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin)
26-6
Biomolecules and Their Synthetic Analogs
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
200132-54-3 Role: CAT (Catalyst use), USES (Uses) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 276248-62-5P ((-)-Lemonomycin) Role: PNU (Preparation, unclassified), PREP (Preparation) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 100-39-0 (Benzyl bromide); 30934-97-5; 81477-94-3; 225938-52-3; 852536-16-4 Role: RCT (Reactant), RACT (Reactant or reagent) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 912654-98-9P; 912654-99-0P; 912655-00-6P; 912655-01-7P; 912655-02-8P; 912655-03-9P; 912655-04-0P; 912655-05-1P; 912655-11-9P; 912655-12-0P; 912655-13-1P; 912655-14-2P; 912655-15-3P; 912655-16-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin); 912655-06-2P; 912655-07-3P; 912655-08-4P; 912655-09-5P; 912655-10-8P Role: SPN (Synthetic preparation), PREP (Preparation) (asym. synthesis of the 1,3-lactol-bridged tetrahydroisoquinoline subunit of (-)-lemonomycin)
Laboratoires
LSPN
Le document apparaît dans
Production scientifique et compétences > SB - Faculté des sciences de base > ISIC - Institut des sciences et ingénierie chimiques > LSPN - Laboratoire de synthèse et produits naturels
Publications validées par des pairs
Travail hors EPFL
Articles de journaux
Publié
Publications validées par des pairs
Travail hors EPFL
Articles de journaux
Publié
Date de création de la notice
2010-11-25