Mono alkylation of alpha -isocyano acetamide to its higher homologues

Alkylation of alpha -isocyanoacetamide with alkyl halide in MeCN at 0 DegC in the presence of cesium hydroxide afforded the mono-alkylated product in good to excellent yield. [on SciFinder (R)]


Published in:
Synlett, 11, 1777-1779
Year:
2006
Keywords:
Note:
CAN 145:418774
25-20
Benzene, Its Derivatives, and Condensed Benzenoid Compounds
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
0936-5214
written in English.
74-88-4 (Methyl iodide); 75-03-6 (Ethyl iodide); 100-11-8 (4-Nitrobenzyl bromide); 100-39-0 (Benzyl bromide); 106-95-6 (Allyl bromide); 106-96-7 (Propargyl bromide); 109-65-9 (1-Bromobutane); 109-89-7 (Diethylamine); 110-91-8 (Morpholine); 123-75-1 (Pyrrolidine); 589-15-1 (4-Bromobenzyl bromide); 1117-97-1 (N-Methoxy-N-methylamine); 3433-80-5 (2-Bromobenzyl bromide); 3958-57-4 (3-Nitrobenzyl bromide); 18880-00-7 (4-tert.-Butylbenzyl bromide); 21852-50-6 (3,4,5-Trimethoxybenzyl bromide); 39687-95-1 (Methyl isocyanoacetate); 58948-98-4 (Potassium isocyanoacetate) Role: RCT (Reactant), RACT (Reactant or reagent) (monoalkylation of alpha -isocyanoacetamide to its higher homologs); 58949-00-1P; 67434-29-1P; 67434-30-4P; 163625-26-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (monoalkylation of alpha -isocyanoacetamide to its higher homologs); 21351-79-1 (Cesium hydroxide) Role: RGT (Reagent), RACT (Reactant or reagent) (monoalkylation of alpha -isocyanoacetamide to its higher homologs); 85059-48-9P; 85059-51-4P; 500555-97-5P; 911817-24-8P; 911817-25-9P; 911817-26-0P; 911817-27-1P; 911817-28-2P; 911817-29-3P; 911817-30-6P; 911817-31-7P; 911817-32-8P; 911817-33-9P; 911817-34-0P; 911817-35-1P; 911817-36-2P; 911817-37-3P; 911817-38-4P; 911817-39-5P Role: SPN (Synthetic preparation), PREP (Preparation) (monoalkylation of alpha -isocyanoacetamide to its higher homologs)
Laboratories:




 Record created 2010-11-25, last modified 2018-03-17


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