Preparation of beta-amino or alpha ,beta-diamino esters derived from serine

The invention relates to the prepn. of esters R1R2NCH2CH(Nu)CO2R3 (R1-R3 are protecting groups and Nu is a nucleophilic group) by reaction of R1R2NCH(CH2-Y)CO2R3 (Y is a leaving group) with a nucleophile. Thus, treatment of (R)-Bn2NCH(CH2O3SMe)CO2Me with NaN3 in MeCN afforded 90% (S)-Bn2NCH2CH(N3)CO2Me. [on SciFinder (R)]


Year:
2006
Publisher:
Application: WO WO, (Shasun Pharma Solutions Limited, UK; Centre National de la Recherche Scientifique (C.N.R.S)).
Keywords:
Note:
CAN 145:397788, 34-2, Amino Acids, Peptides, and Proteins, Patent, written in French., 20061012, 55-21-0 (Benzamide); 56-45-1 (L-Serine); 67-51-6 (3,5-Dimethylpyrazole); 75-64-9; 95-48-7 (o-Cresol); 98-10-2 (Benzenesulfonamide); 103-49-1 (Dibenzylamine); 105-34-0 (Methyl cyanoacetate); 105-53-3 (Diethyl malonate); 105-56-6 (Ethyl cyanoacetate); 106-40-1 (4-Bromoaniline); 108-59-8 (Dimethyl malonate); 108-68-9 (3,5-Dimethylphenol); 108-95-2 (Phenol); 108-98-5 (Thiophenol); 109-73-9 (n-Butylamine); 109-77-3 (Malononitrile); 109-97-7 (Pyrrole); 110-89-4 (Piperidine); 110-91-8 (Morpholine); 120-72-9 (Indole); 122-39-4 (Diphenylamine); 123-75-1 (Pyrrolidine); 123-90-0 (Thiomorpholine); 142-08-5 (2-Hydroxypyridine); 143-33-9 (Sodium cyanide); 150-76-5 (4-Methoxyphenol); 151-50-8 (Potassium cyanide); 288-13-1 (Pyrazole); 288-32-4 (Imidazole); 288-88-0 (1H-1,2,4-Triazole); 497-25-6 (2-Oxazolidinone); 616-45-5 (2-Pyrrolidinone); 1534-08-3; 2577-48-2; 2577-90-4; 2759-28-6 (N-Benzylpiperazine); 15803-02-8 (1-Methyl-4-bromopyrazole); 35161-71-8 (Methylprop-2-ynylamine); 202478-34-0; 219986-64-8 (3-Trifluoromethyl-5-(p-tolyl)-1H-pyrazole); 630389-88-7 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of beta -amino or alpha ,beta -diamino esters derived from serine); 888957-31-1P; 911404-06-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of beta -amino or alpha ,beta -diamino esters derived from serine); 888957-42-4P; 888957-43-5P; 911404-03-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of beta -amino or alpha ,beta -diamino esters derived from serine), A2, FR, 2005-3537, 20050408
Other identifiers:
EPO Family ID: 35544328
Laboratories:




 Record created 2010-11-25, last modified 2018-03-18


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