Infoscience

Patent

Preparation of ecteinascidin alkaloids, such as ecteinascidins 583 and 597

This invention disclosed processes for the asym. synthesis of ecteinascidin alkaloids, including ecteinascidin 773 I (R = OH), ecteinascidin 770 I (R = CN), ecteinascidin 583 II (R1 = H) and ecteinascidin 597 II (R = Me), and their intermediates, such as L-cysteine deriv. III [R3 = C(C6H4-4-OMe)3]. [on SciFinder (R)]

    Keywords: Antitumor agents (asym. synthesis of ecteinascidin alkaloids ; such as ecteinascidins 583 and 597); Alkaloids Role: SPN (Synthetic preparation) ; PREP (Preparation) (asym. synthesis of ecteinascidin alkaloids ; such as ecteinascidins 583 and 597); Stereoselective synthesis (of ecteinascidin alkaloids ; such as ecteinascidins 583 and 597) ; ecteinascidin alkaloid asym synthesis antitumor agent

    Note:

    CAN 146:462418

    31-6

    Alkaloids

    Patent

    written in English.

    20070426

    200132-54-3 Role: CAT (Catalyst use), USES (Uses) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597); 106-95-6; 121-33-5; 488-17-5; 533-31-3 (1,3-Benzodioxol-5-ol); 620-72-4; 645-33-0; 924-44-7; 2799-07-7; 2937-50-0; 17763-80-3; 49757-42-8; 81477-94-3; 102308-32-7; 934969-73-0 Role: RCT (Reactant), RACT (Reactant or reagent) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597); 69404-94-0P; 111726-43-3P; 114899-80-8P (Ecteinascidin 770); 184300-08-1P (Ecteinascidin 583); 244126-22-5P; 244126-41-8P; 259220-89-8P; 308359-33-3P; 366020-68-0P; 366020-69-1P; 402469-27-6P; 686776-20-5P; 686776-22-7P; 686776-23-8P; 686776-24-9P; 686776-25-0P; 686776-27-2P; 854022-02-9P; 874758-51-7P; 874758-53-9P; 874758-54-0P; 874758-55-1P; 874758-56-2P; 874758-58-4P; 874758-59-5P; 874758-60-8P; 874758-61-9P; 874758-62-0P; 874758-63-1P; 874758-64-2P; 874758-65-3P; 874758-66-4P; 874758-67-5P; 874758-68-6P; 874758-69-7P; 874758-70-0P; 874758-71-1P; 874758-72-2P; 874758-73-3P; 874758-74-4P; 874758-76-6P; 874758-78-8P; 874758-82-4P; 925451-68-9P; 925451-73-6P; 925451-75-8P; 925451-76-9P; 925451-77-0P; 925451-78-1P; 925451-79-2P; 925451-80-5P; 925451-84-9P; 925451-85-0P; 925451-86-1P; 925451-87-2P; 925451-88-3P; 925451-89-4P; 925451-91-8P; 925451-92-9P; 925451-95-2P; 925451-96-3P; 925451-97-4P; 934969-68-3P; 934969-69-4P; 934969-71-8P; 934969-72-9P; 934969-74-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597); 114899-77-3P (Ecteinascidin 743); 184300-07-0P (Ecteinascidin 597); 934969-70-7P Role: SPN (Synthetic preparation), PREP (Preparation) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597)

    A2

    US

    2005-728295

    20051020

    Reference

    • EPFL-PATENT-158071

    Record created on 2010-11-25, modified on 2016-08-08

Fulltext

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