Journal article

IBX/TBAB-mediated oxidation of primary amines to nitriles

The combination of o-iodoxybenzoic acid (IBX) and tetrabutylammonium bromide (TBAB) efficiently oxidizes primary amines to the corresponding nitriles in good to excellent yield under mild conditions. The reaction is racemization-free when applied to a chiral lysine deriv. [on SciFinder (R)]


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