Infoscience

Journal article

Total synthesis of horsfiline: a palladium-catalyzed domino Heck-cyanation strategy

A total synthesis of horsfiline (I) has been accomplished featuring a key intramol. palladium-catalyzed domino Heck-cyanation sequence for the formation of the 3,3'-disubstituted oxindole. [on SciFinder (R)]

    Keywords: Cyanation; Heck reaction (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation) ; horsfiline total synthesis domino Heck cyclization cyanation

    Note:

    CAN 152:192342

    31-5

    Alkaloids

    Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.

    Journal

    0936-5214

    written in English.

    1206487-06-0P Role: BYP (Byproduct), PREP (Preparation) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 3375-31-3 Role: CAT (Catalyst use), USES (Uses) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 104-94-9 (p-Anisidine); 867-13-0 (Triethyl phosphonoacetate); 13746-66-2 (Potassium ferricyanate) Role: RCT (Reactant), RACT (Reactant or reagent) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 10029-04-6P; 18437-68-8P; 146309-33-3P; 191348-14-8P; 862885-10-7P; 862885-19-6P; 900254-92-4P; 1206487-00-4P; 1206487-02-6P; 1206487-04-8P; 1206487-08-2P; 1206487-10-6P; 1206487-14-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 136316-07-9P ((+-)-Horsfiline) Role: SPN (Synthetic preparation), PREP (Preparation) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation)

    Reference

    • EPFL-ARTICLE-158049

    Record created on 2010-11-25, modified on 2016-08-08

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