Total synthesis of horsfiline: a palladium-catalyzed domino Heck-cyanation strategy

A total synthesis of horsfiline (I) has been accomplished featuring a key intramol. palladium-catalyzed domino Heck-cyanation sequence for the formation of the 3,3'-disubstituted oxindole. [on SciFinder (R)]


Published in:
Synlett, 18, 2997-2999
Year:
2009
Keywords:
Note:
CAN 152:192342
31-5
Alkaloids
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
0936-5214
written in English.
1206487-06-0P Role: BYP (Byproduct), PREP (Preparation) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 3375-31-3 Role: CAT (Catalyst use), USES (Uses) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 104-94-9 (p-Anisidine); 867-13-0 (Triethyl phosphonoacetate); 13746-66-2 (Potassium ferricyanate) Role: RCT (Reactant), RACT (Reactant or reagent) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 10029-04-6P; 18437-68-8P; 146309-33-3P; 191348-14-8P; 862885-10-7P; 862885-19-6P; 900254-92-4P; 1206487-00-4P; 1206487-02-6P; 1206487-04-8P; 1206487-08-2P; 1206487-10-6P; 1206487-14-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation); 136316-07-9P ((+-)-Horsfiline) Role: SPN (Synthetic preparation), PREP (Preparation) (total synthesis of horsfiline via palladium-catalyzed domino intramol. Heck-cyanation)
Laboratories:




 Record created 2010-11-25, last modified 2018-01-28


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