We conduct an experimental investigation of nonlinearity management in optics using femtosecond pulses and layered Kerr media consisting of glass and air. By examining the propagation properties over several diffraction lengths, we show that wave collapse can be prevented. We corroborate these experimental results with numerical simulations of the (2+1)-dimensional focusing cubic nonlinear Schrödinger equation with piecewise constant coefficients and a theoretical analysis of this setting using a moment method. © 2006 The American Physical Society.