000154897 001__ 154897
000154897 005__ 20190416220654.0
000154897 0247_ $$2doi$$a10.1093/brain/awh040
000154897 022__ $$a0006-8950
000154897 037__ $$aARTICLE
000154897 245__ $$aOut-of-body experience and autoscopy of neurological origin
000154897 269__ $$a2004
000154897 260__ $$bOxford University Press$$c2004
000154897 336__ $$aJournal Articles
000154897 500__ $$aErratum in: Brain. 2004;127(Pt 3):719 + Comment in: Brain. 2004;127(Pt 2):239-42.
000154897 520__ $$aDuring an out-of-body experience (OBE), the experient seems to be awake and to see his body and the world from a location outside the physical body. A closely related experience is autoscopy (AS), which is characterized by the experience of seeing one's body in extrapersonal space. Yet, despite great public interest and many case studies, systematic neurological studies of OBE and AS are extremely rare and, to date, no testable neuroscientific theory exists. The present study describes phenomenological, neuropsychological and neuroimaging correlates of OBE and AS in six neurological patients. We provide neurological evidence that both experiences share important central mechanisms. We show that OBE and AS are frequently associated with pathological sensations of position, movement and perceived completeness of one's own body. These include vestibular sensations (such as floating, flying, elevation and rotation), visual body-part illusions (such as the illusory shortening, transformation or movement of an extremity) and the experience of seeing one's body only partially during an OBE or AS. We also find that the patient's body position prior to the experience influences OBE and AS. Finally, in five patients, brain damage or brain dysfunction is localized to the temporo-parietal junction (TPJ). These results suggest that the complex experiences of OBE and AS represent paroxysmal disorders of body perception and cognition (or body schema). The processes of body perception and cognition, and the unconscious creation of central representation(s) of one's own body based on proprioceptive, tactile, visual and vestibular information-as well as their integration with sensory information of extrapersonal space-is a prerequisite for rapid and effective action with our surroundings. Based on our findings, we speculate that ambiguous input from these different sensory systems is an important mechanism of OBE and AS, and thus the intriguing experience of seeing one's body in a position that does not coincide with its felt position. We suggest that OBE and AS are related to a failure to integrate proprioceptive, tactile and visual information with respect to one's own body (disintegration in personal space) and by a vestibular dysfunction leading to an additional disintegration between personal (vestibular) space and extrapersonal (visual) space. We argue that both disintegrations (personal; personal-extrapersonal) are necessary for the occurrence of OBE and AS, and that they are due to a paroxysmal cerebral dysfunction of the TPJ in a state of partially and briefly impaired consciousness.
000154897 6531_ $$aBody Image
000154897 700__ $$0240593$$g165806$$aBlanke, Olaf
000154897 700__ $$aLandis, Theodor
000154897 700__ $$aSpinelli, Laurent
000154897 700__ $$aSeeck, Margitta
000154897 773__ $$j127$$tBrain : a journal of neurology$$kPt 2$$q243-58
000154897 8564_ $$uhttps://infoscience.epfl.ch/record/154897/files/2004_Blanke_B_obe%20and%20autoscopy%20of%20neurological%20origin.pdf$$zn/a$$s259897$$yPublisher's version
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000154897 917Z8 $$x182396
000154897 937__ $$aEPFL-ARTICLE-154897
000154897 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000154897 980__ $$aARTICLE