000154834 001__ 154834
000154834 005__ 20190316234933.0
000154834 0247_ $$2doi$$a10.1002/ana.21647
000154834 022__ $$a1531-8249
000154834 02470 $$2ISI$$a000267566800011
000154834 037__ $$aARTICLE
000154834 245__ $$aSeeing the phantom: a functional magnetic resonance imaging study of a supernumerary phantom limb
000154834 269__ $$a2009
000154834 260__ $$bWiley-Blackwell$$c2009
000154834 336__ $$aJournal Articles
000154834 520__ $$aOBJECTIVE: Supernumerary phantom limb (SPL) is a rare neurological manifestation where patients with a severe stroke-induced sensorimotor deficit experience the illusory presence of an extra limb that duplicates a real one. The illusion is most often experienced as a somesthetic phantom, but rarer SPLs may be intentionally triggered or seen. Here, we report the case of a left visual, tactile, and intentional SPL caused by right subcortical damage in a nondeluded woman. METHODS: Using functional magnetic resonance imaging, we investigated the multimodal nature of this phantom, which the patient claimed to be able see, use, and move intentionally. The patient participated in a series of sensorimotor and motor imagery tasks involving the right, the left plegic, and the SPL's hand. RESULTS: Right premotor and motor regions were engaged when she imagined that she was scratching her left cheek with her left plegic hand, whereas when she performed the same task with the SPL, additional left middle occipital areas were recruited. Moreover, comparison of responses induced by left cheek (subjectively feasible) versus right cheek scratching (reportedly unfeasible movement) with the SPL demonstrated significant activation in right somesthetic areas. INTERPRETATION: These findings demonstrate that intentional movements of a seen and felt SPL activate premotor and motor areas together with visual and sensory cortex, confirming its multimodal dimension and the reliability of the patient's verbal reports. This observation, interpreted for cortical deafferentation/disconnection caused by subcortical brain damage, constitutes a new but theoretically predictable entity among disorders of bodily awareness.
000154834 6531_ $$aRight-Hemisphere Stroke
000154834 6531_ $$aPrimary Visual-Cortex
000154834 6531_ $$aIllusory Movements
000154834 6531_ $$aHuman-Body
000154834 6531_ $$aAwareness
000154834 6531_ $$aImagery
000154834 6531_ $$aAreas
000154834 6531_ $$aArms
000154834 700__ $$aKhateb, Asaid
000154834 700__ $$aSimon, Stéphane R.
000154834 700__ $$0244844$$g175936$$aDieguez, Sebastian
000154834 700__ $$aLazeyras, François
000154834 700__ $$aMomjian-Mayor, Isabelle
000154834 700__ $$0240593$$g165806$$aBlanke, Olaf
000154834 700__ $$aLandis, Theodor
000154834 700__ $$aPegna, Alan J.
000154834 700__ $$aAnnoni, Jean-Marie
000154834 773__ $$j65$$tAnnals of neurology$$k6$$q698-705
000154834 8564_ $$uhttps://infoscience.epfl.ch/record/154834/files/2009_Khateb_AN_seeing%20the%20phantom%20-%20a%20fmri%20study%20of%20a%20supernumery%20phantom%20limb.pdf$$zn/a$$s584670$$yPublisher's version
000154834 909C0 $$xU11025$$0252325$$pLNCO
000154834 909CO $$qGLOBAL_SET$$pSV$$ooai:infoscience.tind.io:154834$$particle
000154834 917Z8 $$x182396
000154834 917Z8 $$x198754
000154834 937__ $$aEPFL-ARTICLE-154834
000154834 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000154834 980__ $$aARTICLE