000154828 001__ 154828
000154828 005__ 20190316234932.0
000154828 0247_ $$2doi$$a10.1348/174866408X318653
000154828 022__ $$a1748-6645
000154828 02470 $$2ISI$$a000270605100003
000154828 037__ $$aARTICLE
000154828 245__ $$aPreliminary evidence for a fronto-parietal dysfunction in able-bodied participants with a desire for limb amputation
000154828 269__ $$a2009
000154828 260__ $$bBritish Psychological Society$$c2009
000154828 336__ $$aJournal Articles
000154828 520__ $$aBACKGROUND: Reports of able-bodied participants with the persisting desire for limb amputation raise legal and ethical questions that are partly due to insufficient empirical knowledge about the condition. Here, we searched for potential neurological mechanisms in participants with desire for limb amputation in order to help develop adequate nosological classifications, diagnosis, and treatment. METHODS: Semi-structured interviews were carried out with 20 participants who self-identified themselves as able-bodied individuals desiring amputation of a limb. RESULTS: The results suggest that amputation desire is not unspecific, but in most cases specific for a circumscribed part of the body. Most frequently affected was the leg, mostly on the left, non-dominant side. Left-sidedness and limb specificity was associated with elementary and complex somatosensory disturbances of the affected limb akin to those reported by neurological patients. The most frequent neurological co-morbidity was migraine headache. CONCLUSIONS: These results document the existence of an unusual condition in able-bodied participants characterized by a person's desire for the amputation of one or more particular limbs. Left-sidedness, limb specificity and somatosensory disturbances of the affected limb are suggestive of abnormal brain mechanisms in right fronto-parietal cortex. Based on this association we suggest that desire for limb amputation may be conceptualized as asomatognosia due to disturbed integration of multi-sensory information of the affected body parts into a coherent cerebral representation of the own body. This suggestion has to be regarded with caution as we did not perform any neurological examination.
000154828 6531_ $$aAmputation
000154828 6531_ $$aBody Image
000154828 6531_ $$aExtremities
000154828 700__ $$0240593$$g165806$$aBlanke, Olaf
000154828 700__ $$aMorgenthaler, Florence D.
000154828 700__ $$aBrugger, Peter
000154828 700__ $$aOverney, Leila S.
000154828 773__ $$j3$$tJournal of neuropsychology$$k2$$q181-200
000154828 8564_ $$uhttps://infoscience.epfl.ch/record/154828/files/2009_Blanke_JNP%28underReview%29_preliminary%20evidence%20for%20a%20fronto-parietal%20dysfunction%20in%20able-bodied%20participants%20with%20a%20desire%20for%20limb%20amputation.pdf$$zPublisher's version$$s135476$$yPublisher's version
000154828 909C0 $$xU11025$$0252325$$pLNCO
000154828 909C0 $$0252276$$pLIFMET$$xU10984
000154828 909CO $$qGLOBAL_SET$$pSB$$pSV$$particle$$ooai:infoscience.tind.io:154828
000154828 917Z8 $$x182396
000154828 917Z8 $$x198754
000154828 917Z8 $$x148230
000154828 937__ $$aEPFL-ARTICLE-154828
000154828 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000154828 980__ $$aARTICLE