Mechanical, physical and manufacturing properties of cast iron make it attractive for many fields of application, such as cranks and cylinder holds. As in design of all metals, fatigue life prediction is an intrinsic part of the design process of structural sections that are made of cast iron. A methodology to predict high-cycle fatigue life of cast iron is proposed. Stress amplitude-strain amplitude, strain amplitude-number of loading cycles relationships of cast iron are investigated. Also, fatigue life prediction in terms of Smith, Watson and Topper parameter is carried out using the proposed method. Results indicate that the analytical outcomes of the proposed methodology are in good accordance with the experimental data for the two studied types of cast iron; EN-GJS-400 and EN-GJS-600.