Infoscience

Journal article

Interactions of poly(amidoamine) dendrimers with Survanta lung surfactant: The importance of lipid domains

The interaction of generation 5 (G5) and 7 (G7) poly(amidoamine) (PAMAM) dendrimers with mica-supported Survanta bilayers is studied with atomic force microscopy (AFM). In these experiments, Survanta forms distinct gel and fluid domains with differing lipid composition. Nanoscale defects are induced by the PAMAM dendrimers. The positively charged dendrimers remove lipid from the fluid domains at a significantly greater rate than for the gel domains. Dendrimer accumulation on lipid edges and terraces preceding lipid removal has been directly imaged. Immediately following lipid removal, the mica surface is clean, indicating that lipid defects are not induced by dendrimers binding to the mica substrate and displacing the lipid.

    Keywords: atomic-force microscopy ; polycationic polymers ; bilayer disruption ; inhaled particles ; phase-behavior ; cancer-therapy ; hole formation ; morphology ; monolayers ; proteins

    Note:

    Orr, Bg Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA Univ Michigan, Program Biophys, Ann Arbor, MI 48109 USA Univ Michigan, Program Appl Phys, Ann Arbor, MI 48109 USA Univ Michigan, Program Macromol Sci & Engn, Ann Arbor, MI 48109 USA Univ Michigan, Graham Environm Sustainabil Inst, Ann Arbor, MI 48109 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Phys, Ann Arbor, MI 48109 USA Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA Xavier Univ, Dept Chem, New Orleans, LA 70125 USA

    354XP

    Times Cited:0

    Cited References Count:30

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    Record created on 2010-11-05, modified on 2016-08-08

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