The effect of NaF in vitro on the mechanical and material properties of trabecular and cortical bone

High doses of sodium fluoride in bones lead to severe softening, by weakening interfacial properties between the inorg. minerals and the org. components, while leaving mineralization unchanged. This leads to redn. of microdamage and assocd. stress-whitening pointing to a change in failure mode. Accordingly, elastic modulus, failure stress, and indentation-distance increase are decreased, whereas failure strain is increased. [on SciFinder (R)]


Published in:
Adv. Mater. (Weinheim, Ger.), 21, 4, 451-457
Year:
2009
ISSN:
0935-9648
Keywords:
Note:
CAN 150:366841
1-12
Pharmacology
Bioengineering Science Research Group, School of Engineering Science,University of Southampton,Highfield, Southampton,UK.
Journal
7681-49-4 (Sodium fluoride) Role: ADV (Adverse effect, including toxicity), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (effect of sodium fluoride in vitro on mech. and material properties of trabecular and cortical bone)
Laboratories:




 Record created 2010-11-05, last modified 2018-09-13


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